This belongs to a group of medicines called antipsychotics. As the administration of volumes greater than 3 ml is uncomfortable for. This emedtv resource explains the factors that determine a persons fluphenazine dosing. Dec 10, 2018 fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. The onset of action is usually 1 to 3 days and significant effects on psychotic symptoms are usually evident within 2 to 4 days. Fluphenazine decanoate injection fluphenazine decanoate is a longacting parenteral preparation. This ed material has been downloaded from a licensed data provider and is not for distribution, except. Prolixin decanoate fluphenazine decanoate basics, side. Fluphenazine decanoate injection is a sterile solution of fluphenazine decanoate in a suitable vegetable oil.
Fluphenazine hydrochloride injection, usp package insert. There is also a long acting injectable version that may. The products dosage form is injection, and is administered via intramuscular. Fluphenazine decanoate synonyms, fluphenazine decanoate pronunciation, fluphenazine decanoate translation, english dictionary definition of fluphenazine decanoate. Each vial contains 200 mg of dacarbazine the active ingredient, citric acid monohydrate and mannitol. Fluphenazine decanoate injection auromedics pharma llc. See the fda package insert see pregnancy safe medications. Get fluphenazine decanoate at best price with product specifications.
Most of the deaths were linked to heart disease or infection. Fluphenazine decanoate full prescribing information. Haldol decanoate contains the active substance haloperidol as haloperidol decanoate. Fluphenazine decanoate, a human prescription drug labeled by westward pharmaceuticals corp. Fluphenazine decanoate is usually used in patients who have benefited from regular doses of shortacting forms of fluphenazine and who may benefit from longterm maintenance treatment with less frequent dosing. A comparative trial of haloperidol decanoate and fluphenazine decanoate in chronic schizophrenic patients. Sensitive method for the simultaneous measurement of. There is a higher chance of death in older adults who take fluphenazine decanoate injection for mental problems caused by dementia. It is present in oral and injectable forms as the hydrochloride salt, and in the suppositories as the base. Place about 50 mg of fluphenazine decanoate and about 50 mg of usp fluphenazine decanoate dihydrochloride rs in separate, glassstoppered, small centrifuge tubes, and treat each tube as follows.
It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia. Fluphenazine decanoate injection, usp package insert fluphenazine decanoate injection, usp 25 mgml rx only description fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. A twentyweek doubleblind study was conducted to compare the efficacy and sideeffect profile of haloperidol decanoate and fluphenazine decanoate, both given fourweekly, in fiftyone chronic schizophrenic patients. Modecate concentrate 100mg1ml solution for injection ampoules sanofi active ingredients size unit nhs indicative price drug tariff drug tariff price.
Fluphenazine administration to horses may result in characteristic clinical signs of toxicity. Labelingpackage insert label is not available on this site. Fluphenazine decanoate or enanthate injections are administered via im or subcutaneous injection only, do not administer intravenously. Fluphenazine decanoate medicinal forms bnf content. Assay preparation transfer an accurately measured quantity of the injection, equivalent to about 25 mg of fluphenazine decanoate, to a glassstoppered, 50ml volumetric flask. Read all of this leaflet carefully before you start. Use of a wet needle or syringe may cause the solution to become cloudy. Severely agitated patients may be treated initially with a rapidacting phenothiazine compound such as prolixin injection fluphenazine hydrochloride injection uspsee package insert accompanying that product for complete information. Dailymed fluphenazine decanoate injection, solution.
This web page contains comprehensive information about ndc code 0143952901. J2680 hcpcs code for injection, fluphenazine decanoate, up. Add 2 ml of carbon disulfide, shake vigorously for 2 minutes, and centrifuge. Fluphenazine decanoate drugspharmaceuticals with ndc code. Capitals indicate lifethreatening, underlines indicate most frequent. Fluphenazine decanoate information, side effects, warnings. Product information modecate fluphenazine decanoate oily. The basic effects of modecate appear to be no different from those of fluphenazine hydrochloride, with the exception of duration of action.
Mepron oral suspension is contraindicated in patients who develop or have a history of. Fluphenazine decanoate injection, usp is available as a clear, pale yellow solution for intramuscular appropriate dosage. Your doctor may occasionally change your dose to make sure you get. List of the 8 ndc products with the active ingredient fluphenazine decanoate. Add about 20 ml of isopropyl alcohol, insert the stopper, and shake vigorously for at least 1 minute. Phenothiazine, dopaminergic blocker therapeutic class. This emedtv web page further explores the effects of fluphenazine, offers general dosing information for the drug, and lists possible side effects that may occur. Dry the lower, clear layer by filtering through 2 g of. Dacarbazine for injection is reconstituted and administered intravenously ph 34.
Dacarbazine is an anticancer agent designated chemically. Fluphenazine decanoate aka fluphenazine decanoate is a human prescription drug product labeled by westward pharmaceuticals corp. The decanoate salt form of fluphenazine, a phenothiazine with antipsychotic activity. Modecate injection is fluphenazine decanoate in sesame oil with 1. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia. Ndc proprietary name nonproprietary name dosage form route name company name product type. For psychotic patients who have been stabilized on a fixed daily dosage or orally administered prolixin fluphenazine hydrochloride dosage forms, conversion to the longacting injectable prolixin decanoate may be indicated see package insert for prolixin decanoate fluphenazine decanoate injection for conversion information.
Mepron is supplied in 210ml bottles or 5ml foil pouches. Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients. To begin therapy with fluphenazine decanoate injection, the following regimens are suggested. Oct 31, 2017 fluphenazine decanoate injection may be given im or sc. Haldol decanoate side effects, dosage, interactions drugs. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Prolixin decanoate fluphenazine decanoate fda package. Intramuscular depot injection fluphenazine decanoate or. Par pharmaceutical begins shipment of fluphenazine decanoate. Subcutaneous injection fluphenazine decanoate or fluphenazine enanthate. Viroptic trifluridine this product information is intended only for residents of the united states.
Haldol decanoate side effects, dosage, interactions. Fluphenazine decanoate drug bnf content published by. A dry syringe and needle of at least 21 gauge should be used. A comparative trial of haloperidol decanoate and fluphenazine. Fluphenazine belongs to a class of medications called phenothiazines and is also referred to as a neuroleptic. Contraindications fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients, psychoneurotic patients or geriatric patients with confusion andor agitation. In horses, fluphenazine decanoate has been used to provide a persistent sedative effect. Fluphenazine decanoate injection multipledose vial. J2680 is a valid 2020 hcpcs code for injection, fluphenazine decanoate, up to 25 mg or just fluphenazine decanoate 25 mg for short, used in medical care. Fluphenazine decanoate injection, usp package insert. Haloperidol decanoate dose recommendations for elderly patients. Fresenius kabis health hazard evaluation concluded that the oos assay value observed is unlikely to be clinically significant. Modecate concentrate 100mg1ml solution for injection. Dacarbazine for injection is a colorless to an ivory colored solid which is light sensitive.
Fluphenazine decanoate prolixin, permitil, modecate is indicated for the treatment of schizophrenia. Haldol decanoate 50 haloperidol haldol decanoate 100. It is given by mouth, injection into a muscle, or just under the skin. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy eg, chronic schizophrenics. The ndc code 0143952901 is assigned to fluphenazine decanoate also known as. Generally, people who are taking the oral form of fluphenazine usually start at 2. Each ml of haldol decanoate 50 for im injection contains 50 mg haloperidol present as haloperidol decanoate 70. Selected from data included with permission and ed by first databank, inc. As with all medicines, it is possible for a person to take too much prolixin. Jul 29, 2019 severely agitated patients may be treated initially with a rapidacting phenothiazine compound such as prolixin injection fluphenazine hydrochloride injection uspsee package insert accompanying that product for complete information. Administration of haloperidol decanoate in sesame oil results in slow and sustained.
Fluphenazine decanoate drug bnf content published by nice. It is a highly potent behavior modifier with a markedly extended duration of effect. Hcpcs level ii code drugs administered other than oral method, chemotherapy drugs. Your doctor may occasionally change your dose to make sure you get the best results. Fluphenazine decanoate is dissolved in sesame oil for long duration of action. Fluphenazine decanoate vial side effects by likelihood and. Fluphenazine is a prescription drug that is licensed for treating psychotic disorders. It is a highly potent behavior modifier with a markedly extended dura tion of effect and has the following structural formula. Pharmacology fluphenazine is an antipsychotic agent of the phenothiazine class possessing a piperazine side chain.
Anxiolytic, antipsychotic pregnancy risk category c action unclear. Prolixin decanoate fluphenazine decanoate is longacting medicine for stabilizing your mood that must be given by a trained healthcare professional. For example, zuclopenthixol acetate 4 has a short halflife of 36 h in comparison with the decanoate halflife 7 days and a more rapid onset of action 5. It is used in the treatment of chronic psychoses such as schizophrenia, and appears to be about equal in effectiveness to lowpotency antipsychotics like chlorpromazine. Fluphenazine decanoate should be given by deep intramuscular injection. Fluphenazine decanoate injection, usp is a sterile injection, available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per ml. J2680 hcpcs code for injection, fluphenazine decanoate. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy e.
J2680 has been in effect since 01011997 hcpcs code details j2680. Fresenius kabi recall of fluphenazine decanoate injection. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for prolixin decanoate fluphenazine decanoate skip to. Fluphenazine decanoate injection has not been shown effective in the management of behavioral complications in. Mepron is a bright yellow, citrusflavored, oral suspension containing 750 mg of atovaquone per 5 ml. Fluphenazine decanoate is 2432trifluoromethylphenothiazin10ylpropylpiperazin1ylethyl decanoate. Fluphenazine decanoate section after pearls for dosing and use continued fluphenazine 291 pharmacokinetics mean halflife of oral formulation approximately 15 hours mean halflife of intramuscular formulation approximately 6. Each ml of haldol decanoate 50 for im injection contains 50 mg. Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. Fluphenazine decanoate exerts its actions by blocking postsynaptic dopamine d2 receptors in the limbic, cortical system and basal ganglia.
This page also offers tips for those taking the drug. Fluphenazine depot injection solutions must be drawn up using a dry syringe and a needle of at least 21gauge. Par pharmaceutical begins shipment of fluphenazine. Prescribing information thorazine brand of chlorpromazine antipsychotic tranquilizer antiemetic description thorazine chlorpromazine is 103dimethylaminopropyl2chlorphenothiazine, a dimethylamine derivative of phenothiazine. Add 20 ml more of isopropyl alcohol, and repeat the vigorous shaking. Fluphenazine decanoate injection may be given im or sc. Decanoate injection, usp 25 mgml, initially with a. Prolixin fda prescribing information, side effects and uses. When acute symptoms have subsided, 25 mg 1 ml of prolixin decanoate may be administered. Im or subcutaneous sc use providing 25 mg fluphenazine decanoate per ml in a sesame. Haldol should be administered by deep intramuscular injection into the gluteal region. The specific effects of a prolixin overdose will vary, depending on a number of factors, including how much prolixin was taken and whether it was taken with any other. Product monograph fluphenazine decanoate injection.
It is preferable that patients be stabilised on fluphenazine decanoate therapy in hospital. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for prolixin decanoate fluphenazine decanoate. Fluphenazine, sold under the brand names prolixin among others, is an antipsychotic medication. This medication is given by injection into a muscle intramuscularlyim or beneath the skin subcutaneouslysubq by a nurse or doctor. A phenothiazine drug, c22h26f3n3os, used in its hydrochloride and decanoate forms to treat schizophrenia and other psychotic disorders. Prolixin decanoate fluphenazine decanoate is a derivative of phenothiazine. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the.